Side-by-Side Comparison

Tirzepatide vs Semaglutide

Tirzepatide produces approximately 47% more weight loss than semaglutide based on the SURPASS-2 head-to-head trial.

Researched By

Dr. Parmis

Medical Researcher · Western University of Health Sciences

Medically Reviewed By

Adam Kennah, M.D.

Board-Certified Physician

Last clinically reviewed: April 28, 2026 · This page is informational and does not constitute medical advice.

Comparison summary

Tirzepatide produces approximately 47% more weight loss than semaglutide based on the SURPASS-2 head-to-head trial.

For the full clinical evidence, see clinical research and main comparison page.

Compounded semaglutide + tirzepatide · MD/DO oversight

$186/month*

*12-month plan · flat rate · all titration doses