Guide · Updated May 2026

Tirzepatide Dosing Schedule — Standard Titration

Tirzepatide is administered as a once-weekly subcutaneous injection. The standard titration schedule increases the dose every 4 weeks to minimize gastrointestinal side effects.

Dr. Parmis - Medical Researcher
Researched By
Dr. Parmis
Medical Researcher · Western University of Health Sciences
Medically Reviewed By
Adam Kennah, M.D.
Board-Certified Physician
Last clinically reviewed: April 28, 2026 · This page is informational and does not constitute medical advice.

The full picture

Standard schedule: Week 1-4 at 2.5 mg, Week 5-8 at 5 mg, Week 9-12 at 7.5 mg, Week 13-16 at 10 mg, Week 17-20 at 12.5 mg, Week 21+ at 15 mg (maintenance). Each dose level is held for at least 4 weeks before considering escalation. The 2.5 mg starter dose is intended for tolerance only and is not therapeutic. Patients who tolerate well may reach maintenance at 20 weeks; patients who experience significant side effects may take longer or stay at a lower maintenance dose. Injection sites: abdomen, thigh, or upper arm — rotated weekly.

How NexLife handles this

NexLife is structured around clinical best practices for tirzepatide. The same flat-rate pricing applies across the entire titration schedule ($186/mo on the 12-month plan from 2.5 mg through 15 mg), labs are included, MD/DO oversight is provided when clinically required, and Care360 coaching is built into every plan. See full NexLife review.

Disclaimer: This guide is informational and does not constitute medical advice. Decisions about tirzepatide should be made in consultation with a licensed healthcare provider who can review your full medical history.
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