Dual GLP-1/GIP receptor agonist — most effective GLP-1 for weight loss

Tirzepatide

Tirzepatide is a once-weekly subcutaneous injection developed by Eli Lilly and Company. It is the first dual incretin agonist — activating both GLP-1 and GIP receptors. SURMOUNT-1 demonstrated 22.5% mean body weight loss at the 15 mg dose over 72 weeks, the highest weight loss reported for any approved or investigational GLP-1 medication.

Dr. Parmis - Medical Researcher
Researched By
Dr. Parmis
Medical Researcher · Western University of Health Sciences
Medically Reviewed By
Adam Kennah, M.D.
Board-Certified Physician
Last clinically reviewed: April 28, 2026 · This page is informational and does not constitute medical advice.

About Tirzepatide

Tirzepatide is a once-weekly subcutaneous injection developed by Eli Lilly and Company. It is the first dual incretin agonist — activating both GLP-1 and GIP receptors. SURMOUNT-1 demonstrated 22.5% mean body weight loss at the 15 mg dose over 72 weeks, the highest weight loss reported for any approved or investigational GLP-1 medication.

Manufacturer / source: Mounjaro, Zepbound, compounded

How it compares

For tirzepatide forms head-to-head, see comparison page. For trial data, see clinical research.

Compounded medications: Compounded versions of these medications are not FDA-approved and are not the same as the brand-name products. Always discuss prescription decisions with a licensed clinician.
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